Description

8-Benzyloxy-5-((R)-2-Bromo-1-Hydroxyethyl)-1H-Quinolinone is a high-purity, chiral synthetic intermediate of significant importance in advanced pharmaceutical research and development. Its core value lies in its role as a key building block for constructing complex molecules, particularly those targeting specific biological pathways. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries who require reliable, high-quality intermediates for drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of novel active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used as a scaffold or precursor for structure-activity relationship (SAR) studies to optimize drug candidate potency, selectivity, and pharmacokinetic properties.
• Process Chemistry Development: Employed in route scouting and scale-up optimization for the efficient and cost-effective manufacturing of target drug molecules.
• Asymmetric Synthesis: Utilized in reactions that require the introduction of specific stereochemistry due to its defined (R)-configuration at the chiral center.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Product Name	8-Benzyloxy-5-((R)-2-Bromo-1-Hydroxyethyl)-1H-Quinolinone
CAS No.	530084-79-8
Molecular Formula	C18H16BrNO3
Molecular Weight	374.23 g/mol
Synonyms	5-[(1R)-2-Bromo-1-hydroxyethyl]-8-(phenylmethoxy)-1H-quinolin-2-one; (R)-8-Benzyloxy-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one; 8-Benzyloxy-5-[(R)-2-bromo-1-hydroxyethyl]-2(1H)-quinolinone; 1H-Quinolin-2-one, 5-[(1R)-2-bromo-1-hydroxyethyl]-8-(phenylmethoxy)-; 530084-79-8
EINECS	Contact for details

Quality Control

Our 8-Benzyloxy-5-((R)-2-Bromo-1-Hydroxyethyl)-1H-Quinolinone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97% by HPLC), chiral excess, and impurity profile is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.