Description

(8-(Benzyloxy)-5-[(1R)-2-Bromo-1-{[tert-Butyl(Dimethyl)Silyl]Oxy}Ethyl]Quinolin-2(1H)-One ) CAS NO 530084-74-3 is a sophisticated, high-purity organic intermediate featuring a quinolinone core with a benzyl-protected phenol and a chiral, silyl-protected bromohydrin side chain. This compound is of significant value in pharmaceutical research and development, serving as a critical building block for the synthesis of complex bioactive molecules. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing novel drug candidates, particularly in areas requiring chiral specificity and advanced protecting group strategies.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for oncology, CNS, and anti-infective therapies.
• Process Chemistry: Used in route scouting and scale-up studies for the efficient, stereoselective synthesis of complex target molecules.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fine Chemical Synthesis: Employed in the custom synthesis of specialty chemicals, advanced materials, and other high-value organic compounds requiring its unique functional group array.
• Academic Research: Utilized in university and institutional laboratories for methodological development in organic synthesis and asymmetric catalysis.

Basic Information

Product Name	(8-(Benzyloxy)-5-[(1R)-2-Bromo-1-{[tert-Butyl(Dimethyl)Silyl]Oxy}Ethyl]Quinolin-2(1H)-One
CAS No.	530084-74-3
Molecular Formula	C24H30BrNO3Si
Molecular Weight	488.50 g/mol
Synonyms	5-[(1R)-2-Bromo-1-{[tert-Butyl(dimethyl)silyl]oxy}ethyl]-8-(phenylmethoxy)-2(1H)-quinolinone; 8-Benzyloxy-5-[(1R)-2-bromo-1-(tert-butyldimethylsilyloxy)ethyl]quinolin-2(1H)-one; TBDMS-protected Bromo Quinolinone Intermediate; (R)-5-(2-Bromo-1-((tert-butyldimethylsilyl)oxy)ethyl)-8-(benzyloxy)quinolin-2(1H)-one; CAS 530084-74-3; Quinolin-2(1H)-one derivative, TBDMS ether; Chiral Bromohydrin Quinolinone Building Block
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and chiral analysis. A detailed Certificate of Analysis (COA) is provided with each batch, documenting identity, purity, chiral purity, and impurity profiles. We support compliance with ICH guidelines for impurities and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container for extended periods to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.