Description

(-)-1,2-Bis((2R,5R)-2,5-Diphenylphospholano)Ethane(1,5-Cyclooctadiene)Rhodium (I) Tetrafluoroborate is a highly specialized, chiral organometallic complex that serves as a premier asymmetric hydrogenation catalyst. Its value lies in enabling the production of enantiomerically pure intermediates, which are critical for the efficacy and safety of modern pharmaceuticals. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require high stereoselectivity in synthetic routes.

Application

• Asymmetric Hydrogenation Catalyst: For the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Pharmaceutical Manufacturing: Key for producing active pharmaceutical ingredients (APIs) with high enantiomeric excess, such as chiral amines and amino acid derivatives.
• Fine Chemical Synthesis: Used in the preparation of specialty chemicals and advanced materials requiring precise stereochemical control.
• Agrochemical Research: Development of chiral herbicides, fungicides, and pesticides with improved activity and environmental profiles.
• Academic & Industrial R&D: A valuable tool for methodological development in organic synthesis and catalysis studies.
• Process Chemistry Optimization: Scaling up asymmetric transformations from laboratory to pilot plant and commercial production.

Basic Information

Product Name	(-)-1,2-Bis((2R,5R)-2,5-Diphenylphospholano)Ethane(1,5-Cyclooctadiene)Rhodium (I) Tetrafluoroborate
CAS No.	528565-84-6
Molecular Formula	C46H48BF4P2Rh
Molecular Weight	852.52 g/mol
Synonyms	(R,R)-Me-DuPhos Rhodium(I) Tetrafluoroborate COD Complex; [Rh((R,R)-Me-DuPhos)(COD)]BF4; (R,R)-Me-DuPhos Rhodium Catalyst; (-)-1,2-Bis((2R,5R)-2,5-Dimethylphospholano)ethane(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; Rh-(R,R)-Me-DuPhos(COD)BF4; Rhodium(I) (1,5-cyclooctadiene)((2R,5R)-2,5-dimethyl-1-phenylphospholano-κP)ethane-1,2-diyl) tetrafluoroborate; Asymmetric Hydrogenation Catalyst Rh-MeDuPhos
EINECS	Contact for details

Quality Control

Every batch of our chiral rhodium catalyst is produced and tested under strict inert atmosphere conditions to prevent decomposition. We employ advanced analytical techniques including NMR, HPLC, and elemental analysis to verify identity, chiral purity, and catalytic activity. A comprehensive Certificate of Analysis (COA) detailing assay, enantiomeric excess (ee) of relevant test reactions, and residual solvent levels is provided with each shipment to ensure compliance with your research and cGMP development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is moisture-sensitive and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will lead to decomposition and loss of catalytic activity. The storage area should be cool, dry, and well-ventilated.

Specification

Item	Specification
Appearance	Orange to red crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 99.0% ee (by chiral HPLC or derived from test reaction)
Rhodium Content (ICP-MS)	11.0 - 12.5 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.