Description

1H-Indazole-6-Carboxamide,n-(1R,3R,4S)-1-Azabicyclo[2.2.1]Hept-3-Yl-(9Ci) is a high-purity, advanced pharmaceutical intermediate characterized by its complex, stereochemically defined bicyclic structure. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. Pharmaceutical R&D teams and fine chemical manufacturers need this material for developing next-generation therapeutics, where its precise stereochemistry is essential for achieving desired biological activity and selectivity.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel drug candidates, especially in neurology and psychiatry.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• API Development: Serves as a sophisticated synthon for constructing complex molecular architectures in active pharmaceutical ingredient (API) manufacturing.
• Biochemical Tool Compound: Potential use in pharmacological research as a ligand or probe for studying specific biological pathways and receptors.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for cutting-edge organic synthesis and drug discovery projects.

Basic Information

Item	Detail
Product Name	1H-Indazole-6-Carboxamide,n-(1R,3R,4S)-1-Azabicyclo[2.2.1]Hept-3-Yl-(9Ci)
CAS No.	521278-05-7
Molecular Formula	C14H16N4O
Molecular Weight	256.31 g/mol
Synonyms	(1R,3R,4S)-N-(1-Azabicyclo[2.2.1]hept-3-yl)-1H-indazole-6-carboxamide; (1R,3R,4S)-3-[(1H-Indazol-6-ylcarbonyl)amino]-1-azabicyclo[2.2.1]heptane; 1H-Indazole-6-carboxamide, N-[(1R,3R,4S)-1-azabicyclo[2.2.1]hept-3-yl]-; 521278-05-7; (1R,3R,4S)-1-Azabicyclo[2.2.1]hept-3-amine, N-(1H-indazol-6-ylcarbonyl)-; Stereoisomer of ABT-724 intermediate
EINECS	Contact for details

Quality Control

Every batch of our 1H-Indazole-6-Carboxamide,n-(1R,3R,4S)-1-Azabicyclo[2.2.1]Hept-3-Yl-(9Ci) is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including chiral purity analysis, to ensure compliance with the high standards required for pharmaceutical development. Certificates of Analysis (COA) documenting identity, purity, and stereochemical integrity are available upon request. We support development with GMP-grade material upon inquiry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.