Description

2,5-Bis(Trifluoromethyl)-Phenyhydrazine(Hcl) is a specialized organofluorine building block of significant interest in advanced chemical synthesis. This compound matters for its role in introducing the highly stable and lipophilic trifluoromethyl group into target molecules, which is a critical modification in modern pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases where the trifluoromethyl group enhances metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and liquid crystals with unique thermal, chemical, and optical properties.
• Organic Synthesis Reagent: Employed in palladium-catalyzed cross-coupling reactions, such as Buchwald-Hartwig amination, for the construction of complex nitrogen-containing heterocycles.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research focused on exploring new methodologies for C-N bond formation and fluorinated compound synthesis.

Basic Information

Product Name	2,5-Bis(Trifluoromethyl)-Phenyhydrazine(Hcl)
CAS No.	518057-67-5
Molecular Formula	C9H7ClF6N2
Molecular Weight	292.61 g/mol
Synonyms	2,5-Bis(trifluoromethyl)phenylhydrazine hydrochloride; 1-[2,5-Bis(trifluoromethyl)phenyl]hydrazine hydrochloride; 2,5-Bis(trifluoromethyl)benzenephenylhydrazine HCl; (2,5-Bis(trifluoromethyl)phenyl)hydrazine hydrochloride; 2,5-Bis(trifluoromethyl)phenylhydrazine HCl salt; Hydrazine, [2,5-bis(trifluoromethyl)phenyl]-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our 2,5-Bis(Trifluoromethyl)-Phenyhydrazine(Hcl) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.