Description

3-Chloro-6-Fluoroquinolin-8-Amine is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogenated quinoline scaffold enables precise molecular modifications. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries focused on creating new molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel quinolone and fluoroquinolone antibiotic candidates, leveraging its halogenated structure for enhanced bioactivity.
• Agrochemical Research: Serves as a building block for developing new generation herbicides, fungicides, and pesticides with improved efficacy and selectivity.
• Material Science: Used in the research and development of organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient quinoline core.
• Chemical Biology: Employed as a molecular probe or tag in biochemical research to study enzyme interactions and cellular processes.
• Dye & Pigment Synthesis: Acts as an intermediate for creating specialized heterocyclic dyes and pigments with specific light-absorption properties.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	3-Chloro-6-Fluoroquinolin-8-Amine
CAS No.	515170-52-2
Molecular Formula	C9H5ClFN2
Molecular Weight	196.60 g/mol
Synonyms	8-Amino-3-chloro-6-fluoroquinoline; 3-Chloro-6-fluoro-8-aminoquinoline; 6-Fluoro-3-chloroquinolin-8-amine; 515170-52-2; Quinoline, 8-amino-3-chloro-6-fluoro-; 3-Chloro-6-fluoroquinoline-8-ylamine; 8-Quinolinamine, 3-chloro-6-fluoro-
EINECS	Contact for details

Quality Control

Our 3-Chloro-6-Fluoroquinolin-8-Amine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive quality assurance, with products typically meeting specifications suitable for research and pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every batch upon request, supporting your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.