Description

n-(5-Aminopentyl)Maleimide Hydrochloride Salt is a high-purity, bifunctional chemical linker featuring a reactive maleimide group and a primary amine, activated as its hydrochloride salt. This compound is essential for creating stable, site-specific conjugations between biomolecules and various surfaces or probes in advanced research and diagnostics. It is primarily utilized by scientists and manufacturers in the fields of bioconjugation, proteomics, and pharmaceutical development for antibody-drug conjugate (ADC) research, protein labeling, and surface functionalization.

Application

• Bioconjugation Reagent: For the covalent coupling of peptides, proteins, or antibodies to other molecules, nanoparticles, or solid supports via the maleimide-thiol chemistry.
• Antibody-Drug Conjugate (ADC) Research: Serves as a key linker component for attaching cytotoxic payloads to monoclonal antibodies in targeted cancer therapy development.
• Surface Functionalization: Used to modify biosensor chips, microarray slides, or chromatography media by introducing reactive amine groups for further immobilization.
• Protein and Peptide Labeling: Enables the site-specific attachment of fluorescent dyes, affinity tags (e.g., biotin), or other probes to biomolecules for detection and analysis.
• Crosslinking Agent: Facilitates the study of protein-protein interactions or the creation of stable protein complexes.
• Polymer Chemistry: Acts as a monomer or modifier for synthesizing functional polymers with tailored reactive sites.

Basic Information

Product Name	n-(5-Aminopentyl)Maleimide Hydrochloride Salt
CAS No.	510709-83-8
Molecular Formula	C9H15ClN2O2
Molecular Weight	218.68 g/mol
Synonyms	5-Maleimidopentylamine hydrochloride; N-(5-Aminopentyl)maleimide HCl; 1-(5-Aminopentyl)-1H-pyrrole-2,5-dione hydrochloride; Maleimidocaproylamine hydrochloride; 6-Maleimidohexylamine hydrochloride (common naming variant); CAP-MAL HCl; Amino-PEG5-maleimide hydrochloride (related linear chain analog); N-(5-Aminoamyl)maleimide hydrochloride
EINECS	Contact for details

Quality Control

Our n-(5-Aminopentyl)Maleimide Hydrochloride Salt is manufactured under strict quality protocols to ensure batch-to-batch consistency and high reactivity. Each lot undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and titration for active content. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your research and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool environment. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccant or under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Titration)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO; partially soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.