Description

4,7-Methano-1H-Isoindol-1-One,3,3-Difluoro-2,3,3A,4,7,7A-Hexahydro-2-Methyl-,(3Ar,4S,7R,7As)-Rel-(9Ci) is a high-value, stereochemically defined fluorinated bicyclic lactam building block. This compound matters as a sophisticated chiral intermediate, enabling the synthesis of complex molecules with precise three-dimensional architecture for advanced research and development. It is primarily needed by pharmaceutical and agrochemical R&D teams working on novel active ingredients, particularly those targeting neurological or metabolic pathways where its unique fluorinated methanoisoindolone core can impart critical bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and enzyme inhibitor targets.
• Agrochemical Active Ingredient Synthesis: Used in creating advanced herbicides, fungicides, or insecticides where the fluorinated structure enhances lipophilicity and environmental stability.
• Advanced Material Chemistry: Serves as a monomer or precursor for specialty polymers and liquid crystals requiring specific stereochemistry and fluorine content.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship (SAR) explorations to investigate the impact of the difluoromethano bridge on potency and selectivity.
• Asymmetric Catalysis Ligand Precursor: Potential building block for novel chiral ligands or organocatalysts used in enantioselective synthesis.
• Fluorine Chemistry Research: A valuable compound for academic and industrial research into the synthesis and reactivity of complex fluorinated heterocycles.

Basic Information

Product Name	4,7-Methano-1H-Isoindol-1-One,3,3-Difluoro-2,3,3A,4,7,7A-Hexahydro-2-Methyl-,(3Ar,4S,7R,7As)-Rel-(9Ci)
CAS No.	507233-89-8
Molecular Formula	C10H11F2NO
Molecular Weight	199.20 g/mol
Synonyms	rel-(3aR,4S,7R,7aS)-3,3-Difluoro-2-methyl-2,3,3a,4,7,7a-hexahydro-4,7-methano-1H-isoindol-1-one; (rel)-(3aR,4S,7R,7aS)-3,3-Difluoro-2-methylhexahydro-4,7-methano-1H-isoindol-1-one; 3,3-Difluoro-2-methylhexahydro-4,7-methano-1H-isoindol-1-one, (3aR,4S,7R,7aS)-rel-; Difluorinated Methanoisoindolone Chiral Building Block; Fluorinated Bicyclic Lactam Intermediate
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles, typically determined by HPLC, GC, NMR, and chiral analysis methods. Our quality commitment ensures the material meets the stringent requirements for pharmaceutical R&D and supports regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.