Description

(2S)-2-Ethyl-8-Methyl-1-Thia-4,8-Diazaspiro[4,5]Decan-3-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic structure containing sulfur and nitrogen heteroatoms. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within central nervous system (CNS) and metabolic disorder research pipelines.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in drug discovery programs for constructing spirocyclic scaffolds to explore structure-activity relationships (SAR).
• Preclinical Development: Employed in the production of compounds for pharmacological profiling, toxicology studies, and early-stage formulation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in API production.

Basic Information

Item	Details
Product Name	(2S)-2-Ethyl-8-Methyl-1-Thia-4,8-Diazaspiro[4,5]Decan-3-One
CAS No.	503431-81-0
Molecular Formula	C11H20N2OS
Molecular Weight	228.35 g/mol
Synonyms	(2S)-2-Ethyl-8-methyl-1-thia-4,8-diazaspiro[4.5]decan-3-one; 1-Thia-4,8-diazaspiro[4.5]decan-3-one, 2-ethyl-8-methyl-, (2S)-; (S)-2-Ethyl-8-methyl-1-thia-4,8-diazaspiro[4,5]decan-3-one; Spirocyclic thiadiazinone derivative; CAS 503431-81-0
EINECS	Contact for details

Quality Control

Every batch of (2S)-2-Ethyl-8-Methyl-1-Thia-4,8-Diazaspiro[4,5]Decan-3-One is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting results for assay, chiral purity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.