Description

8-(5-Bromo-Pyridin-2-Yl)-1,4-Dioxa-8-Aza-Spiro[4.5]Decane CAS NO 501954-42-3 is a high-value, multifunctional heterocyclic building block featuring a brominated pyridine moiety fused with a spirocyclic ketal-protected amine. This compound is critical for research and development in advanced organic synthesis, offering a versatile scaffold for constructing complex molecular architectures. It is primarily sought after by pharmaceutical, agrochemical, and advanced materials researchers for applications in medicinal chemistry, ligand design, and the development of novel functional molecules.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the bromopyridine and spirocyclic structures.
• Ligand and Catalyst Development: Acts as a sophisticated ligand precursor in transition metal catalysis for cross-coupling and other asymmetric transformations.
• Material Science: Employed in the synthesis of organic semiconductors, metal-organic frameworks (MOFs), and other functional materials requiring rigid, nitrogen-containing heterocycles.
• Chemical Biology Probe Synthesis: Utilized to create molecular probes for studying enzyme function and biological pathways due to its modifiable handles.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Item	Detail
Product Name	8-(5-Bromo-Pyridin-2-Yl)-1,4-Dioxa-8-Aza-Spiro[4.5]Decane
CAS No.	501954-42-3
Molecular Formula	C14H17BrN2O2
Molecular Weight	325.20 g/mol
Synonyms	8-(5-Bromopyridin-2-yl)-1,4-dioxa-8-azaspiro[4.5]decane; 1,4-Dioxa-8-azaspiro[4.5]decane, 8-(5-bromo-2-pyridinyl)-; 5-Bromo-2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)pyridine; 8-(5-Bromo-2-pyridyl)-1,4-dioxa-8-azaspiro[4.5]decane; 8-(5-Bromopyridin-2-yl)-1,4-dioxa-8-azaspiro[4.5]decane; 5-Bromo-2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)pyridine; 8-(5-Bromo-2-pyridinyl)-1,4-dioxa-8-azaspiro[4.5]decane
EINECS	Contact for details

Quality Control

Our production of 8-(5-Bromo-Pyridin-2-Yl)-1,4-Dioxa-8-Aza-Spiro[4.5]Decane adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, which include data from HPLC, NMR, and mass spectrometry. Our quality systems are designed to support cGMP and ISO standards for pharmaceutical and fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.