Description

(R)-Boc-4-(Trifluoromethyl)-β-Phe-Oh is a high-purity, non-natural amino acid derivative featuring a chiral center and a trifluoromethyl group. This compound is a critical chiral building block for the synthesis of complex bioactive molecules, offering enhanced metabolic stability and lipophilicity. It is primarily utilized by pharmaceutical R&D and process chemistry teams in the development of peptide-based therapeutics, enzyme inhibitors, and other advanced drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs) and peptide drugs.
• Peptidomimetics Development: Used to incorporate the trifluoromethylphenylalanine moiety into peptide backbones to improve binding affinity and pharmacokinetic properties.
• Protease Inhibitor Research: Serves as a core structural element in the design of inhibitors for various proteases.
• Chemical Biology & Probe Synthesis: Employed in the creation of labeled compounds and molecular probes for studying biological mechanisms.
• Agrochemical Research: Potential intermediate in the development of advanced pesticides and herbicides with specific chiral activity.
• Material Science: Can be used in the synthesis of specialized polymers and advanced organic materials.

Basic Information

Product Name	(R)-Boc-4-(Trifluoromethyl)-β-Phe-Oh
CAS No.	501015-19-6
Molecular Formula	C₁₅H₁₈F₃NO₄
Molecular Weight	333.31 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-3-[4-(trifluoromethyl)phenyl]propanoic acid; Boc-(R)-4-CF3-Phe-OH; (R)-N-Boc-4-Trifluoromethylphenylalanine; (R)-N-(tert-Butoxycarbonyl)-4-(trifluoromethyl)phenylalanine; (R)-Boc-4-(Trifluoromethyl)phenylalanine; tert-Butyl (R)-(3-(4-(trifluoromethyl)phenyl)-1-carboxy-1-oxopropan-2-yl)carbamate; (R)-Boc-CF3-Phe-OH
EINECS	Contact for details

Quality Control

Our (R)-Boc-4-(Trifluoromethyl)-β-Phe-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.