Description

Boc-(R)-3-Amino-3-(2-Bromo-Phenyl)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring a chiral center and a bromo-aromatic side chain, protected by a tert-butoxycarbonyl (Boc) group. This compound is a critical chiral building block for the synthesis of complex molecules, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Peptidomimetics Synthesis: Used to incorporate a constrained, brominated phenylalanine analog into peptide chains to modulate bioactivity, stability, and receptor binding affinity.
• Chemical Biology & Proteomics: Serves as a specialized building block for creating activity-based probes, enzyme inhibitors, and labeled peptides for biochemical studies.
• Asymmetric Synthesis: Employed in medicinal chemistry for the construction of complex, enantiomerically pure molecules due to its defined (R)-configuration.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity chiral intermediates.

Basic Information

Product Name	Boc-(R)-3-Amino-3-(2-Bromo-Phenyl)-Propionic Acid
CAS No.	500789-07-1
Molecular Formula	C₁₄H₁₈BrNO₄
Molecular Weight	344.20 g/mol
Synonyms	(R)-3-((tert-Butoxycarbonyl)amino)-3-(2-bromophenyl)propanoic acid; (R)-2-Boc-amino-3-(2-bromophenyl)propionic acid; Boc-D-2-BrPhe-OH; Boc-(R)-2-Bromophenylalanine; tert-Butyl (R)-(1-(2-bromophenyl)-3-carboxy-3-oxopropyl)carbamate; (R)-3-(Boc-amino)-3-(2-bromophenyl)propanoic acid; N-Boc-3-amino-3-(2-bromophenyl)propionic acid
EINECS	Contact for details

Quality Control

Our Boc-(R)-3-Amino-3-(2-Bromo-Phenyl)-Propionic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral excess, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.