Description

(1R,2S,4S)-Rel-2-Amino-7-Boc-7-Azabicyclo[2.2.1]Heptane CAS NO 500556-93-4 is a high-purity, protected chiral amine building block featuring a rigid bicyclic scaffold. This compound is critically important for its role as a key intermediate in the synthesis of complex, biologically active molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists working on new drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas requiring stereochemically defined, constrained structures.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in neuroscience and antiviral research.
• Medicinal Chemistry: Used in lead optimization and structure-activity relationship (SAR) studies to introduce conformational rigidity and specific stereochemistry into drug-like molecules.
• Peptidomimetics: Serves as a constrained, non-natural amino acid analog for designing protease inhibitors and other bioactive peptides.
• Asymmetric Synthesis: Acts as a chiral auxiliary or precursor for catalysts in stereoselective chemical transformations.
• Chemical Biology: Employed in the synthesis of molecular probes and tool compounds for studying biological pathways and target engagement.
• Process Chemistry: Used in the scale-up and route development for the commercial manufacturing of advanced pharmaceutical intermediates.

Basic Information

Product Name	(1R,2S,4S)-Rel-2-Amino-7-Boc-7-Azabicyclo[2.2.1]Heptane
CAS No.	500556-93-4
Molecular Formula	C11H20N2O2
Molecular Weight	212.29 g/mol
Synonyms	7-tert-Butoxycarbonyl-7-azabicyclo[2.2.1]heptan-2-amine, (1R,2S,4S)-rel-; 2-Amino-7-[(1,1-dimethylethoxy)carbonyl]-7-azabicyclo[2.2.1]heptane; 7-Boc-7-azabicyclo[2.2.1]heptan-2-amine; 7-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 2-amino-, 1,1-dimethylethyl ester; BOC-7-Azanorbornane-2-amine; rel-(1R,2S,4S)-2-Amino-7-Boc-7-azabicyclo[2.2.1]heptane; tert-Butyl (1R,2S,4S)-rel-2-amino-7-azabicyclo[2.2.1]heptane-7-carboxylate
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Quality Control

Our (1R,2S,4S)-Rel-2-Amino-7-Boc-7-Azabicyclo[2.2.1]Heptane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial identification tests, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.