Description

3-Mercapto-3-Methylbutanoic Acid is a specialized sulfur-containing carboxylic acid featuring a tertiary thiol group. This unique structure makes it a valuable chiral building block and intermediate in organic synthesis, particularly for introducing sterically hindered thiol functionalities. It is primarily sought after by research and development chemists and process engineers in the pharmaceutical and fine chemical industries for applications in drug discovery, asymmetric synthesis, and the development of novel materials.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring a sterically hindered thiol moiety.
• Asymmetric Synthesis: Used as a precursor or ligand in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Flavor & Fragrance Industry: Potential intermediate for synthesizing sulfur-containing flavor compounds that contribute to meaty, roasted, or tropical notes.
• Polymer Modification: Acts as a chain transfer agent or functional monomer to introduce thiol groups into polymers, altering their properties for adhesives or coatings.
• Bioconjugation Chemistry: Useful in linking molecules to proteins or other biomolecules via thiol-reactive chemistry (e.g., maleimide coupling).
• Organic Synthesis Reagent: Employed in various organic transformations, including nucleophilic additions and the preparation of thioesters.

Basic Information

Product Name	3-Mercapto-3-Methylbutanoic Acid
CAS No.	59729-24-7
Molecular Formula	C5H10O2S
Molecular Weight	134.20 g/mol
Synonyms	3-Methyl-3-sulfanylbutanoic acid; 3-Methyl-3-mercaptobutanoic acid; tert-Butylthiolacetic acid; 3-Mercapto-3-methylbutyric acid; 3-Methyl-3-thiolbutanoic acid; (RS)-3-Mercapto-3-methylbutanoic acid; (±)-3-Mercapto-3-methylbutanoic acid
EINECS	Contact for details

Quality Control

Our 3-Mercapto-3-Methylbutanoic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. A Certificate of Analysis (COA) detailing specific results for purity, identity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its light-sensitive nature, containers should be kept in the original packaging or amber glass until use to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.