Description

(6R,7R)-3',4',6,8-Tetrahydro-6',7'-Dimethoxy-2',6-Dimethylspiro[7H-Indeno[4,5-D]-1,3-Dioxole-7,1'(2'H)-Isoquinolin]-6-Ol is a complex spirocyclic organic compound with a defined stereochemistry, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its precise molecular architecture makes it valuable for constructing sophisticated pharmacophores and functional materials. This high-purity intermediate is essential for research and development in the pharmaceutical and fine chemical sectors, particularly for programs targeting neurological and cardiovascular pathways.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of potential drug candidates, especially for central nervous system (CNS) and cardiovascular targets.
• Asymmetric Synthesis: Utilized as a sophisticated building block in stereoselective reactions to create complex molecules with high enantiomeric purity.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and the development of novel bioactive compounds.
• Fine Chemical Production: Intermediate in the manufacture of specialty chemicals, dyes, and advanced materials requiring specific stereochemistry.
• Academic & R&D Laboratories: Used in methodological development and exploratory synthesis within university and industrial research settings.
• Process Chemistry Development: Employed in scaling up synthetic routes for potential active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(6R,7R)-3',4',6,8-Tetrahydro-6',7'-Dimethoxy-2',6-Dimethylspiro[7H-Indeno[4,5-D]-1,3-Dioxole-7,1'(2'H)-Isoquinolin]-6-Ol
CAS No.	59614-35-6
Molecular Formula	C24H27NO5
Molecular Weight	409.48 g/mol
Synonyms	(6R,7R)-6-Hydroxy-6',7'-dimethoxy-2',6-dimethylspiro[indeno[4,5-d][1,3]dioxole-7,1'(2'H)-isoquinoline]-3',4',6,8-tetrahydro; Spiro[indeno[4,5-d][1,3]dioxole-7,1'(2'H)-isoquinoline]-6-ol, 3',4',6,8-tetrahydro-6',7'-dimethoxy-2',6-dimethyl-, (6R,7R)-; (6R,7R)-6-Hydroxy-2',6-dimethyl-6',7'-dimethoxyspiro[indeno[4,5-d][1,3]dioxole-7,1'(2'H)-isoquinoline]-3',4',6,8-tetrahydro; CAS 59614-35-6; Spirocyclic Isoquinoline Derivative; Chiral Spiro Indenodioxole Intermediate
EINECS	Contact for details

Quality Control

Our production of (6R,7R)-3',4',6,8-Tetrahydro-6',7'-Dimethoxy-2',6-Dimethylspiro[7H-Indeno[4,5-D]-1,3-Dioxole-7,1'(2'H)-Isoquinolin]-6-Ol adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, identity confirmation (IR, NMR), and quantification of key impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect the light-sensitive compound from degradation and to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.