Description

1-Methyl-7-Oxo-4,7-Dihydro-1H-Pyrazolo[4,3-B]Pyridine-6-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting complex therapeutic areas. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in innovative drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex heterocyclic APIs, especially for central nervous system (CNS) and anti-inflammatory targets.
• Drug Discovery Research: Used in medicinal chemistry for lead optimization and the development of new chemical entities (NCEs) within the pyrazolopyridine scaffold.
• Process Chemistry Development: Serves as a standard or starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Academic & Industrial R&D: Employed in chemical biology studies and as a reagent for exploring new synthetic methodologies.
• Reference Standard: Utilized as an analytical standard for quality control and method validation in API manufacturing.

Basic Information

Product Name	1-Methyl-7-Oxo-4,7-Dihydro-1H-Pyrazolo[4,3-B]Pyridine-6-Carboxylic Acid Ethyl Ester
CAS No.	59376-44-2
Molecular Formula	C11H11N3O3
Molecular Weight	233.22 g/mol
Synonyms	Ethyl 1-Methyl-7-oxo-4,7-dihydro-1H-pyrazolo[4,3-b]pyridine-6-carboxylate; 1-Methyl-7-oxo-4,7-dihydro-1H-pyrazolo[4,3-b]pyridine-6-carboxylic acid ethyl ester; 6-Carbethoxy-1-methyl-1,4-dihydro-7H-pyrazolo[4,3-b]pyridin-7-one; 1-Methyl-7-oxo-6-ethoxycarbonyl-4,7-dihydro-1H-pyrazolo[4,3-b]pyridine; 59376-44-2; Pyrazolo[4,3-b]pyridine-6-carboxylic acid, 1-methyl-4,7-dihydro-7-oxo-, ethyl ester
EINECS	Contact for details

Quality Control

Our 1-Methyl-7-Oxo-4,7-Dihydro-1H-Pyrazolo[4,3-B]Pyridine-6-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.