Description

4-Chlorothiophene-3-Carboxylic Acid is a versatile heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its bifunctional structure, featuring both a reactive carboxylic acid group and a halogenated thiophene ring, enabling precise molecular construction. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced herbicides, fungicides, and insecticides with tailored activity profiles.
• Material Science Research: Used in the synthesis of functionalized thiophene monomers for conductive polymers and organic electronic materials.
• Ligand and Catalyst Development: The carboxylic acid moiety allows for the creation of complex chelating ligands used in homogeneous catalysis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses serving the fine chemical and life science sectors.

Basic Information

Product Name	4-Chlorothiophene-3-Carboxylic Acid
CAS No.	59337-81-4
Molecular Formula	C5H3ClO2S
Molecular Weight	162.59 g/mol
Synonyms	3-Carboxy-4-chlorothiophene; 4-Chloro-3-thiophenecarboxylic Acid; 4-Chloro-thiophene-3-carboxylic acid; 4-Chloro-3-carboxythiophene; 3-Thiophenecarboxylic acid, 4-chloro-; Thiophene-3-carboxylic acid, 4-chloro-
EINECS	Contact for details

Quality Control

Our 4-Chlorothiophene-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. Certificates of Analysis (COA) with complete batch-specific data are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.