Description

3-Quinolinecarbonyl Chloride,4-Hydroxy-7-(Trifluoromethyl)- is a high-value, multi-functional chemical intermediate characterized by its reactive acid chloride group and substituted quinoline core. This compound matters for its role as a critical building block in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for enhanced biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic semiconductors, fluorescent dyes, and photoactive polymers due to the quinoline scaffold's electronic properties.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-Quinolinecarbonyl Chloride,4-Hydroxy-7-(Trifluoromethyl)-
CAS No.	59197-90-9
Molecular Formula	C11H5ClF3NO2
Molecular Weight	275.61 g/mol
Synonyms	4-Hydroxy-7-(trifluoromethyl)quinoline-3-carbonyl chloride; 7-(Trifluoromethyl)-4-hydroxyquinoline-3-carboxylic acid chloride; 4-Hydroxy-7-trifluoromethylquinoline-3-carboxylic acid chloride; 3-Carboxy-4-hydroxy-7-trifluoromethylquinoline chloride; 4-Hydroxy-7-trifluoromethyl-3-quinolinecarbonyl chloride; 7-Trifluoromethyl-4-hydroxy-quinoline-3-carbonyl chloride; 4-Hydroxy-7-(trifluoromethyl)-3-quinolinecarboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarbonyl Chloride,4-Hydroxy-7-(Trifluoromethyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to cGMP and ISO standards ensures reliable supply for demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its reactivity as an acid chloride and sensitivity to moisture, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.