Description

3-(p-Tolyl)Spiro[Isobenzofuran-1(3H),4'-Piperidine] is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic molecular architecture. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel therapeutic agents targeting the central nervous system. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its spirocyclic scaffold.
• API Development: Employed in the development and scale-up processes for new active pharmaceutical ingredients.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in pharmaceutical manufacturing.
• Academic & Institutional Research: Utilized in university and institutional labs for exploratory synthetic chemistry and pharmacological studies.
• Contract Research Organizations (CROs): Essential for CROs providing custom synthesis and drug discovery services to the biopharma industry.

Basic Information

Product Name	3-(p-Tolyl)Spiro[Isobenzofuran-1(3H),4'-Piperidine]
CAS No.	59143-05-4
Molecular Formula	C20H21NO
Molecular Weight	291.39 g/mol
Synonyms	3-(4-Methylphenyl)spiro[2-benzofuran-1,4'-piperidine]; 3-(4-Methylphenyl)-1,3-dihydrospiro[2-benzofuran-1,4'-piperidine]; 3-(p-Tolyl)-1,3-dihydrospiro[isobenzofuran-1,4'-piperidine]; Spiro[isobenzofuran-1(3H),4'-piperidine], 3-(4-methylphenyl)-; 3-(4-Methylphenyl)spiro[isobenzofuran-1(3H),4'-piperidine]; 59143-05-4; p-Tolyl Spiro Isobenzofuran Piperidine
EINECS	Contact for details

Quality Control

Our 3-(p-Tolyl)Spiro[Isobenzofuran-1(3H),4'-Piperidine] is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to protect the compound from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.