Description

(2R)-2-(4-Hydroxyphenyl)Propionic Acid, also known as (R)-(4-Hydroxyphenyl)(Methyl)Acetic Acid or 4-[(1R)-1-Carboxyethyl]Phenol, is a high-purity chiral building block of significant commercial and research interest. This compound matters as a key intermediate in the synthesis of enantiomerically pure pharmaceuticals and fine chemicals, where its defined stereochemistry is critical for biological activity and process control. It is primarily needed by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and advanced material sectors for developing new active ingredients and chiral catalysts.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the production of non-steroidal anti-inflammatory drugs (NSAIDs) and other active pharmaceutical ingredients (APIs) requiring the (R)-enantiomer configuration.
• Agrochemical Synthesis: Used in the research and development of chiral herbicides, fungicides, and plant growth regulators where specific stereochemistry enhances efficacy and reduces environmental impact.
• Chiral Catalyst & Ligand Preparation: Serves as a starting material for synthesizing sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Biochemical Research: Employed in enzymatic studies and as a standard for analytical method development in chiral separation techniques like HPLC and SFC.
• Fine Chemical Production: A building block for specialty chemicals, flavors, and fragrances that benefit from enantiopure precursors.
• Material Science: Potential monomer or modifier in the synthesis of chiral polymers and advanced functional materials.

Basic Information

Product Name	(2R)-2-(4-Hydroxyphenyl)Propionic Acid
CAS No.	59092-88-5
Molecular Formula	C9H10O3
Molecular Weight	166.17 g/mol
Synonyms	(R)-2-(4-Hydroxyphenyl)propionic Acid; (R)-(4-Hydroxyphenyl)(Methyl)Acetic Acid; 4-[(1R)-1-Carboxyethyl]Phenol; (R)-4-Hydroxyhydratropic Acid; (R)-HPPA; (R)-2-(p-Hydroxyphenyl)propanoic Acid; (R)-p-Hydroxyhydratropic Acid; (R)-2-(4-Hydroxyphenyl)propanoic Acid
EINECS	Contact for details

Quality Control

Our (2R)-2-(4-Hydroxyphenyl)Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure compliance with high-purity standards suitable for pharmaceutical R&D and synthesis. Key parameters including chiral purity (enantiomeric excess), chemical purity, and identity are verified. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its nature of being easily oxidized, long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.