Description

(±)-7R,8T-Dihydroxy-9T,10T-Epoxy-7,8,9,10-Tetrahydrobenzo[a]pyrene is a high-purity, advanced synthetic intermediate and reference standard of significant interest in biochemical and toxicological research. This compound is critical for studies investigating the metabolic activation pathways and DNA adduct formation of polycyclic aromatic hydrocarbons (PAHs). It is primarily utilized by research institutions, pharmaceutical R&D departments, and analytical laboratories focused on carcinogenesis, mutagenicity testing, and metabolic profiling.

Application

• Biochemical Research: Used as a key intermediate in studying the metabolic activation of Benzo[a]pyrene (BaP) to its ultimate carcinogenic forms.
• Toxicology Studies: Serves as a precise reference standard in assays for DNA damage and adduct quantification, essential for understanding chemical carcinogenesis.
• Analytical Method Development: Employed for calibrating and validating analytical techniques such as HPLC-MS and GC-MS in environmental and biological monitoring.
• Pharmaceutical R&D: Acts as a tool compound in early-stage discovery for screening compounds that may inhibit specific metabolic pathways involved in toxicity.
• Academic Research: Fundamental reagent for university laboratories exploring the mechanisms of PAH-induced toxicity and cellular repair processes.
• Standards Manufacturing: Used by producers of certified reference materials (CRMs) for quality control and assurance in analytical testing laboratories.

Basic Information

Product Name	(±)-7R,8T-Dihydroxy-9T,10T-Epoxy-7,8,9,10-Tetrahydrobenzo[a]pyrene
CAS No.	58917-67-2
Molecular Formula	C₂₀H₁₄O₃
Molecular Weight	302.32 g/mol
Synonyms	Benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide (anti); BPDE; (+/-)-anti-Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide; 7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; anti-BPDE; B[a]PDE; 7,8-Diol-9,10-epoxide of Benzo[a]pyrene; (±)-anti-BP-7,8-dihydrodiol-9,10-epoxide
EINECS	Contact for details

Quality Control

Our production of (±)-7R,8T-Dihydroxy-9T,10T-Epoxy-7,8,9,10-Tetrahydrobenzo[a]pyrene adheres to stringent quality protocols to ensure batch-to-batch consistency and purity for sensitive research applications. Each lot is characterized using advanced spectroscopic and chromatographic techniques. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. Allow the container to reach room temperature in a desiccator before opening to prevent condensation. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light tan solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0 %
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.