Description

Benzo(A)Pyrene-9,10-Dihydrodiol is a crucial dihydrodiol metabolite of the polycyclic aromatic hydrocarbon Benzo[a]pyrene, a well-studied environmental pollutant and procarcinogen. This compound is of significant value in biochemical and toxicological research for investigating metabolic activation pathways, DNA adduct formation, and the mechanisms of chemical carcinogenesis. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and environmental testing facilities focused on cancer research, toxicology studies, and metabolic profiling.

Application

• Biochemical Research Standard: Serves as a critical reference standard and intermediate in studies of polycyclic aromatic hydrocarbon (PAH) metabolism and activation.
• Toxicology & Carcinogenesis Studies: Used to investigate the metabolic pathways that convert procarcinogens like Benzo[a]pyrene into ultimate carcinogenic species, specifically the formation of the highly reactive Benzo[a]pyrene diol epoxide (BPDE).
• DNA Adduct Formation Analysis: Essential for in vitro and in vivo studies examining how reactive metabolites bind to DNA, a key event in the initiation of chemical carcinogenesis.
• Enzyme Activity Assays: Employed as a substrate to study the activity and specificity of cytochrome P450 enzymes (e.g., CYP1A1) and epoxide hydrolase involved in PAH bioactivation.
• Environmental Exposure Biomarker Development: Used in the development and validation of analytical methods (e.g., HPLC, GC-MS) to detect and quantify PAH metabolites in biological samples for biomonitoring.
• Pharmaceutical R&D: Utilized in drug discovery programs targeting cancer prevention or chemoprevention strategies that aim to inhibit the metabolic activation of procarcinogens.

Basic Information

Product Name	Benzo(A)Pyrene-9,10-Dihydrodiol
CAS No.	58886-98-9
Molecular Formula	C₂₀H₁₄O₂
Molecular Weight	286.32 g/mol
Synonyms	Benzo[a]pyrene-9,10-dihydrodiol; 9,10-Dihydroxy-9,10-dihydrobenzo[a]pyrene; trans-Benzo[a]pyrene-9,10-dihydrodiol; BP-9,10-diol; 9,10-Dihydrobenzo[a]pyrene-9,10-diol; BaP-9,10-dihydrodiol; (±)-trans-9,10-Dihydroxy-9,10-dihydrobenzo[a]pyrene
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure high purity and consistency, which is critical for sensitive research applications. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and chromatographic data is available upon request to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and ensure long-term stability. Allow the container to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Off-white to pale yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.