Description

(+)-1,2-Methylenedioxy-5,6,6Aα,7-Tetrahydro-4H-Dibenzo[De,G]Quinoline CAS NO 58846-21-2 is a high-purity, chiral alkaloid derivative belonging to the aporphine class, characterized by its complex tetracyclic structure. This compound serves as a critical intermediate and reference standard in advanced pharmaceutical research and development. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in neuroscience and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel therapeutic agents targeting neurological pathways.
• Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical manufacturing (HPLC, GC, LC-MS).
• Neuroscience Research: Investigated for its potential pharmacological activity and receptor binding affinity in central nervous system studies.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies and the design of new chemical entities.
• Process Chemistry: Utilized in route scouting and optimization for the scalable synthesis of complex active pharmaceutical ingredients (APIs).
• Academic Research: Employed in university laboratories for studies in organic synthesis, stereochemistry, and alkaloid chemistry.

Basic Information

Product Name	(+)-1,2-Methylenedioxy-5,6,6Aα,7-Tetrahydro-4H-Dibenzo[De,G]Quinoline
CAS No.	58846-21-2
Molecular Formula	C₁₈H₁₇NO₂
Molecular Weight	279.33 g/mol
Synonyms	(+)-Bulbocapnine methylenedioxy derivative; (6aS)-1,2-Methylenedioxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline; (R)-Bulbocapnine precursor; Aporphine alkaloid derivative; 5,6,6a,7-Tetrahydro-1,2-methylenedioxy-4H-dibenzo[de,g]quinoline; (6aR)-1,2,3,10b-Tetrahydro-6H-benzofuro[2,3-c]quinoline-6,9-diol methylene acetal; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (+)-1,2-Methylenedioxy-5,6,6Aα,7-Tetrahydro-4H-Dibenzo[De,G]Quinoline is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided and available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 98.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.