Description

2-C-Methyl-D-Erythritol is a high-purity, four-carbon sugar alcohol derivative, a key intermediate in the non-mevalonate (MEP/DOXP) pathway for isoprenoid biosynthesis. This compound is of significant interest in biochemical and pharmaceutical research for its role in studying and inhibiting essential metabolic processes in plants and certain pathogens. It serves as a critical building block and reference standard for researchers and manufacturers in the fields of agrochemical development, antibiotic research, and metabolic pathway analysis.

Application

• Biochemical Research: Critical intermediate for studying the methylerythritol phosphate (MEP) pathway in bacteria, apicomplexan parasites, and plant plastids.
• Agrochemical Development: Used as a precursor or target molecule in the research and synthesis of novel herbicides that selectively disrupt plant isoprenoid synthesis.
• Pharmaceutical Intermediates: Serves as a chiral building block in the synthesis of potential antimicrobial agents targeting pathogens reliant on the MEP pathway, such as *Mycobacterium tuberculosis* and *Plasmodium falciparum*.
• Metabolic Pathway Inhibitors: Acts as a reference compound for the development and screening of fosmidomycin analogs and other inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR/IspC).
• Enzymology Studies: Utilized as a substrate or standard in enzymatic assays for DXR and other enzymes within the MEP pathway.
• Nutritional Science: Investigated for its potential metabolic effects and applications as a specialty sugar alcohol.

Basic Information

Product Name	2-C-Methyl-D-Erythritol
CAS No.	58698-37-6
Molecular Formula	C5H12O4
Molecular Weight	136.15 g/mol
Synonyms	2-C-Methylerythritol; (2R,3S)-2-C-Methyl-D-erythritol; 2-C-Methyl-D-threitol; 2-C-Methylerythritol, D-; 1,3,4-Trihydroxy-2-methylbutane; 2-Methyl-D-erythritol; 2-C-ME; MEP pathway intermediate
EINECS	Contact for details

Quality Control

Our 2-C-Methyl-D-Erythritol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation and clumping. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.