Description

4-Chloro-3-(Trifluoromethyl)Cinnamic Acid is a high-purity, multi-functional cinnamic acid derivative distinguished by its unique trifluoromethyl and chloro substituents. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block in organic synthesis, enabling the introduction of lipophilic and electron-withdrawing groups. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of small molecule drugs, particularly in oncology and anti-inflammatory research.
• Agrochemical Synthesis: Used in the production of novel herbicides and pesticides, leveraging the biological activity of the trifluoromethyl group.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for advanced electronic materials due to its rigid, conjugated structure.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Heck) and as a precursor for more complex heterocyclic compounds.
• Chemical Research & Development: Used in academic and industrial R&D for exploring new synthetic pathways and structure-activity relationships.
• Fluorinated Compound Library Synthesis: Essential for creating specialized screening libraries in drug discovery programs.

Basic Information

Product Name	4-Chloro-3-(Trifluoromethyl)Cinnamic Acid
CAS No.	58537-09-0
Molecular Formula	C10H6ClF3O2
Molecular Weight	250.60 g/mol
Synonyms	(E)-3-[4-Chloro-3-(trifluoromethyl)phenyl]acrylic acid; (E)-4-Chloro-3-(trifluoromethyl)cinnamic acid; 3-(4-Chloro-3-(trifluoromethyl)phenyl)-2-propenoic acid; trans-4-Chloro-3-(trifluoromethyl)cinnamic acid; 4-Chloro-α-(trifluoromethyl)cinnamic acid; 58537-09-0; 4-Chloro-3-trifluoromethylcinnamic acid
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-(Trifluoromethyl)Cinnamic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.