Description

(1R,2R)-1,2-Bis(4-Methoxyphenyl)Ethylenediamine is a high-purity chiral diamine compound of significant importance in asymmetric synthesis and pharmaceutical development. Its rigid, C2-symmetric structure makes it an exceptionally valuable ligand and building block for creating enantiomerically pure catalysts and active pharmaceutical ingredients (APIs). This product is essential for research and production teams in the pharmaceutical, agrochemical, and fine chemical sectors who require reliable, high-quality chiral auxiliaries to ensure the stereochemical integrity of their final products.

Application

• Asymmetric Catalyst Ligand: Serves as a privileged chiral scaffold for the synthesis of salen-type and other transition metal catalysts used in enantioselective reactions like epoxidation, cyclopropanation, and Diels-Alder reactions.
• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders and cardiovascular diseases where specific stereochemistry is critical for efficacy.
• Chiral Resolution Agent: Used to separate enantiomers of racemic carboxylic acids or other compounds via diastereomeric salt formation.
• Polymer Chemistry: Employed in the production of chiral polymers and resins with specific optical properties for advanced material science applications.
• Agrochemical Synthesis: Utilized in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators to enhance activity and reduce environmental impact.
• Academic & Process R&D: A vital reagent for universities and corporate R&D laboratories exploring new methodologies in asymmetric catalysis and organocatalysis.

Basic Information

Product Name	(1R,2R)-1,2-Bis(4-Methoxyphenyl)Ethylenediamine
CAS No.	58520-03-9
Molecular Formula	C₁₆H₂₀N₂O₂
Molecular Weight	272.34 g/mol
Synonyms	(1R,2R)-(-)-1,2-Bis(4-methoxyphenyl)ethylenediamine; (R,R)-1,2-Bis(4-methoxyphenyl)-1,2-ethanediamine; (R,R)-DMBEDA; (R,R)-DMPEN; (1R,2R)-1,2-Di(4-methoxyphenyl)ethylenediamine; (R,R)-1,2-Di-p-anisylethylenediamine; (R,R)-Bis(4-methoxyphenyl)ethylenediamine; Jacobsen's Ligand (variant)
EINECS	Contact for details

Quality Control

Our (1R,2R)-1,2-Bis(4-Methoxyphenyl)Ethylenediamine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for sensitive asymmetric synthesis. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation and light, prolonged exposure to air or direct light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	118 - 122 °C
Specific Rotation [α]²⁰D	-105° to -115° (c=1 in CHCl₃)
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.