Description

(+)-trans-4 5-Bis(Iodomethyl)-2,2-Dimethyl-1 3-Dioxolane is a high-purity, chiral building block featuring two reactive iodomethyl groups protected within a dioxolane acetal framework. This compound matters for its role as a versatile synthon in the stereoselective synthesis of complex molecules, offering chemists precise control over molecular architecture. It is primarily needed by research and development teams in the pharmaceutical and fine chemical industries for applications in medicinal chemistry, asymmetric synthesis, and the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized as a building block for constructing stereodefined carbon chains and cyclic structures in fine chemical production.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• Ligand and Catalyst Development: Used in the preparation of chiral ligands, organocatalysts, and other auxiliaries for enantioselective transformations.
• Polymer Chemistry: Potential monomer or cross-linking agent for creating specialized polymers with unique properties.
• Academic & Industrial R&D: A valuable reagent for methodological development and exploratory synthesis in organic chemistry.

Basic Information

Product Name	(+)-trans-4 5-Bis(Iodomethyl)-2,2-Dimethyl-1 3-Dioxolane
CAS No.	58342-57-7
Molecular Formula	C8H14I2O2
Molecular Weight	396.00 g/mol
Synonyms	(+)-trans-4,5-Bis(iodomethyl)-2,2-dimethyl-1,3-dioxolane; (4R,5R)-4,5-Bis(iodomethyl)-2,2-dimethyl-1,3-dioxolane; (R,R)-4,5-Bis(iodomethyl)-2,2-dimethyl-1,3-dioxolane; D-4,5-Bis(iodomethyl)-2,2-dimethyl-1,3-dioxolane; trans-4,5-Diiodomethyl-2,2-dimethyldioxolane; Acetonide of (R,R)-1,2,3,4-Tetrahydroxybutane Diiodide Derivative; Chiral Dioxolane Iodide Synthon
EINECS	Contact for details

Quality Control

Our (+)-trans-4 5-Bis(Iodomethyl)-2,2-Dimethyl-1 3-Dioxolane is manufactured under strict quality control protocols to ensure high chemical and chiral purity. Each batch is analyzed using advanced techniques including HPLC, GC, and NMR to confirm identity, assay, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.