Description

o-Mesitylenesulfonyl Hydroxylamine (MSH or o-MsONH2) is a specialized, highly reactive hydroxylamine derivative primarily used as a versatile aminating and oxidizing agent in organic synthesis. Its core value lies in its ability to introduce nitrogen functionalities under mild conditions, enabling the synthesis of complex molecules with high selectivity and yield. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries, where it facilitates the construction of key intermediates for active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the preparation of oximes, hydroxamic acids, and N-O containing heterocycles, which are crucial scaffolds in drug discovery.
• Agrochemical Production: Used in the synthesis of herbicides, fungicides, and insecticides that require specific nitrogen-oxygen bond formations.
• Polymer & Material Science: Employed as a functionalization agent to introduce amine or hydroxylamine groups onto polymer backbones, modifying surface properties and reactivity.
• Peptide & Protein Modification: Facilitates selective chemical modifications of amino acid side chains, such as cysteine, for bioconjugation and labeling studies.
• Catalyst & Ligand Development: Serves as a precursor for generating novel metal complexes and ligands used in asymmetric catalysis.
• Organic Methodology Development: A fundamental tool in academic and industrial R&D for developing new C-N and C-O bond-forming reactions.

Basic Information

Product Name	o-Mesitylenesulfonyl Hydroxylamine
CAS No.	58042-39-0
Molecular Formula	C9H13NO3S
Molecular Weight	215.27 g/mol
Synonyms	MSH; o-MsONH2; 2,4,6-Trimethylbenzenesulfonylhydroxylamine; Mesitylenesulfonylhydroxylamine; o-Mesitylenesulfonylhydroxylamine; 2-Mesitylenesulfonylhydroxylamine; (2,4,6-Trimethylphenyl)sulfonylhydroxylamine; o-MSH Reagent
EINECS	Contact for details

Quality Control

Our o-Mesitylenesulfonyl Hydroxylamine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for demanding synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity determination, to meet exacting customer specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its nature as an easily oxidized compound, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, open flames, and incompatible materials such as strong reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	95 - 100 °C
Loss on Drying	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.