Description

o-(2,3,4,5,6-Pentafluorobenzyl)Hydroxylamine Hydrochloride is a specialized fluorinated organic building block and derivatization reagent. This compound is highly valued for its role as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily used by R&D chemists and process development scientists working on novel active ingredients, analytical method development, and material science.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of drug candidates, especially those requiring a pentafluorobenzyl-hydroxylamine moiety for bioactivity or as a synthetic handle.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where fluorination enhances stability and efficacy.
• Analytical Derivatization Reagent: Employed in gas chromatography (GC) and liquid chromatography (LC) for the sensitive detection and quantification of carbonyl compounds (aldehydes, ketones) via oxime formation.
• Material Science Research: Serves as a precursor for creating fluorinated polymers or surface modifiers with unique properties.
• Bioconjugation Chemistry: Useful for labeling biomolecules or modifying surfaces in diagnostic assay development.
• Cross-coupling Reactions: Acts as a reagent in palladium-catalyzed and other metal-mediated coupling reactions to construct complex aromatic systems.

Basic Information

Item	Details
Product Name	o-(2,3,4,5,6-Pentafluorobenzyl)Hydroxylamine Hydrochloride
CAS No.	57981-02-9
Molecular Formula	C7H5ClF5NO
Molecular Weight	249.57 g/mol
Synonyms	O-(Pentafluorobenzyl)hydroxylamine hydrochloride; 2,3,4,5,6-Pentafluorobenzyloxyamine hydrochloride; PFBHA hydrochloride; (Pentafluorobenzyl)hydroxylamine HCl; Hydroxylamine, O-[(2,3,4,5,6-pentafluorophenyl)methyl]-, hydrochloride; O-(Perfluorobenzyl)hydroxylamine hydrochloride; Pentafluorobenzyl hydroxylamine hydrochloride
EINECS	Contact for details

Quality Control

Our o-(2,3,4,5,6-Pentafluorobenzyl)Hydroxylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under dry conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.