Description

Boc-N-Me-Tyr(2,6-Dichloro-Bzl)-OH is a protected, non-natural tyrosine derivative used as a critical building block in advanced peptide synthesis. This compound matters because it provides researchers and manufacturers with a precisely functionalized amino acid analog, enabling the development of peptides with enhanced stability, modified biological activity, and tailored physicochemical properties. It is primarily needed by pharmaceutical R&D teams, peptide synthesis service providers, and academic research groups focused on developing novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of modified tyrosine residues into peptide chains.
• Peptidomimetic Drug Discovery: Used to create peptide analogs with improved metabolic stability and receptor binding affinity for therapeutic targets.
• Bioconjugation and Labeling: The protected phenolic group allows for selective deprotection and subsequent conjugation with fluorescent dyes, affinity tags, or other functional molecules.
• Structure-Activity Relationship (SAR) Studies: Essential for synthesizing peptide libraries to investigate the role of specific tyrosine modifications on biological function.
• GPCR Ligand Development: Employed in the synthesis of peptide-based ligands for G-protein-coupled receptors, where tyrosine residues often play a crucial role.
• Antibiotic Peptide Research: Used to engineer novel antimicrobial peptides with halogenated aromatic rings for enhanced potency.

Basic Information

Product Name	Boc-N-Me-Tyr(2,6-Dichloro-Bzl)-OH
CAS No.	57817-43-3
Molecular Formula	C22H25Cl2NO5
Molecular Weight	454.34 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-N-methyl-O-(2,6-dichlorobenzyl)-L-tyrosine; Boc-N-methyl-O-(2,6-dichlorobenzyl)tyrosine; tert-Butyl N-methyl-N-[(2S)-3-[4-[(2,6-dichlorophenyl)methoxy]phenyl]-1-oxo-1-[(2,2,2-trifluoroacetyl)amino]propan-2-yl]carbamate (related protected form); Boc-Tyr(2,6-Cl2-Bzl)-OH, N-Me derivative; (2S)-2-[(tert-Butoxycarbonyl)(methyl)amino]-3-[4-[(2,6-dichlorophenyl)methoxy]phenyl]propanoic acid; Boc-N-Me-Tyr(2,6-DiCl-Bzl)-OH; Fmoc-N-Me-Tyr(2,6-Dichloro-Bzl)-OH precursor.
EINECS	Contact for details

Quality Control

Our Boc-N-Me-Tyr(2,6-Dichloro-Bzl)-OH is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and chiral analysis to verify enantiomeric integrity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage (over 12 months), consider storing at 2-8°C under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Specific Rotation	-15° to -25° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.