Description

Estradiol Bis(tert-Butyldimethylsilyl)Ether is a key protected intermediate in advanced organic synthesis, specifically designed for the selective manipulation of steroid hormone frameworks. This compound is critically important for researchers and manufacturers requiring high-purity building blocks for complex pharmaceutical development. It is primarily utilized in the synthesis of novel estradiol derivatives and other steroidal compounds within the pharmaceutical and life sciences research sectors.

Application

• Pharmaceutical Intermediate: A crucial protected precursor in the multi-step synthesis of novel estradiol analogs and other steroidal active pharmaceutical ingredients (APIs).
• Steroid Chemistry Research: Used in academic and industrial R&D for exploring structure-activity relationships (SAR) by allowing selective functionalization at other reactive sites on the estradiol molecule.
• Process Chemistry: Employed in the development and scale-up of synthetic routes for hormone-based therapeutics, where the tert-butyldimethylsilyl (TBDMS) protecting groups provide stability under various reaction conditions.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in laboratories analyzing steroidal compounds and their synthetic intermediates.

Basic Information

Product Name	Estradiol Bis(tert-Butyldimethylsilyl)Ether
CAS No.	57711-41-8
Molecular Formula	C32H54O2Si2
Molecular Weight	526.94 g/mol
Synonyms	Estradiol 3,17-Bis-O-(tert-butyldimethylsilyl) Ether; 3,17-Bis-O-(tert-Butyldimethylsilyl)estradiol; Estradiol Di-TBDMS Ether; E2 Di-TBDMS; 1,3,5(10)-Estratriene-3,17β-diol, 3,17-Bis-O-[(1,1-dimethylethyl)dimethylsilyl]-; 17β-Estradiol Bis(tert-butyldimethylsilyl) Ether
EINECS	Contact for details

Quality Control

Our Estradiol Bis(tert-Butyldimethylsilyl)Ether is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.