Description

(+)-8-Phenylmenthol CAS NO 57707-91-2 is a high-purity, chiral auxiliary and resolving agent derived from menthol. This compound is critically valued for its ability to induce high levels of stereoselectivity in asymmetric synthesis, particularly in Diels-Alder reactions and conjugate additions. It is an essential building block for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to produce enantiomerically pure intermediates and active ingredients.

Application

• Chiral Auxiliary in Asymmetric Synthesis: Widely employed to control stereochemistry in carbon-carbon bond-forming reactions.
• Resolution of Racemic Mixtures: Used as a resolving agent for the separation of enantiomers via diastereomeric salt or derivative formation.
• Pharmaceutical Intermediate: Key starting material or chiral inductor in the synthesis of complex drug molecules and bioactive compounds.
• Catalyst and Ligand Modification: Serves as a precursor for chiral ligands used in transition metal catalysis.
• Fine Chemical Production: Facilitates the manufacture of enantiomerically enriched flavors, fragrances, and specialty chemicals.
• Academic and R&D Laboratories: A standard reagent for methodological development in organic and medicinal chemistry research.

Basic Information

Product Name	(+)-8-Phenylmenthol
CAS No.	57707-91-2
Molecular Formula	C16H24O
Molecular Weight	232.36 g/mol
Synonyms	(1R,2S,5R)-2-(1-Phenylethyl)-5-methylcyclohexanol; (1R,2S,5R)-8-Phenylmenthol; (+)-(1R,2S,5R)-8-Phenylmenthol; (1R,2S,5R)-2-(α-Methylbenzyl)-5-methylcyclohexanol; 8-Phenylmenthol, (+)-; D-8-Phenylmenthol; (R)-8-Phenylmenthol; Phenylmenthol
EINECS	Contact for details

Quality Control

Our (+)-8-Phenylmenthol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for synthetic applications. A detailed Certificate of Analysis (COA) providing specifications for identity, purity, and enantiomeric excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	70 - 74 °C
Specific Rotation [α]20/D	+25° to +30° (c=1 in CHCl3)
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.