Description

trans-7,8-Dihydroxy-7,8-Dihydro-Benzo(A)Pyrene is a key dihydrodiol metabolite of the polycyclic aromatic hydrocarbon Benzo(a)pyrene (BaP). This compound matters significantly as a crucial intermediate in toxicological and metabolic studies, particularly for investigating the metabolic activation pathways of BaP into its ultimate carcinogenic forms. Researchers in pharmaceutical development, environmental toxicology, and analytical chemistry need this high-purity reference standard to calibrate instruments, validate analytical methods, and conduct mechanistic studies on DNA adduct formation and mutagenicity.

Application

• Biochemical Research: Used as a critical intermediate in studying the metabolic activation pathway of Benzo(a)pyrene (BaP) to its ultimate carcinogenic diol epoxide.
• Toxicology & Carcinogenicity Studies: Serves as a reference standard in assays investigating DNA adduct formation, mutagenicity, and the mechanisms of PAH-induced carcinogenesis.
• Analytical Chemistry: Employed as a high-purity calibration standard for HPLC, LC-MS, and GC-MS methods in environmental and biological monitoring.
• Pharmaceutical Development: Utilized in research focused on understanding drug metabolism interactions with PAHs and in developing potential chemopreventive agents.
• Environmental Science: Acts as a marker compound in research assessing human exposure to polycyclic aromatic hydrocarbons and their biological impact.
• Academic Research: Fundamental tool in university and institutional labs for teaching and advanced research on chemical carcinogenesis and xenobiotic metabolism.

Basic Information

Product Name	trans-7,8-Dihydroxy-7,8-Dihydro-Benzo(A)Pyrene
CAS No.	57404-88-3
Molecular Formula	C20H14O2
Molecular Weight	286.32 g/mol
Synonyms	(±)-trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene; Benzo[a]pyrene 7,8-dihydrodiol; trans-BP-7,8-diol; 7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene; BaP 7,8-dihydrodiol; 7,8-Dihydrobenzo[a]pyrene-7,8-diol; BPDE precursor; Benzo[a]pyrene-7,8-diol
EINECS	Contact for details

Quality Control

Our trans-7,8-Dihydroxy-7,8-Dihydro-Benzo(A)Pyrene is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all quality parameters are provided and available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light tan solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in DMSO, methanol, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.