Description

(1S)-1,2,3,4,4Aβ,9,10,10Aα-Octahydro-1-Methylphenanthrene-1β-Carboxylic Acid Methyl Ester is a high-purity, stereochemically defined intermediate of significant interest in advanced organic synthesis. This compound matters for its role as a key chiral building block in the development of complex pharmaceutical molecules and fine chemicals. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing intricate polycyclic frameworks.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those with steroidal or complex polycyclic structures.
• Asymmetric Synthesis: Used as a starting material or intermediate in catalytic asymmetric reactions to introduce specific stereocenters.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies in drug discovery programs targeting various disease pathways.
• Fine Chemical Production: Employed in the multi-step synthesis of high-value specialty chemicals, fragrances, and advanced materials.
• Reference Standard: Supplied as a high-purity analytical standard for method development and quality control in laboratory settings.
• Process Chemistry Development: Used for scaling up and optimizing synthetic routes in pilot plants and manufacturing process development.

Basic Information

Product Name	(1S)-1,2,3,4,4Aβ,9,10,10Aα-Octahydro-1-Methylphenanthrene-1β-Carboxylic Acid Methyl Ester
CAS No.	57378-56-0
Molecular Formula	C₁₇H₂₂O₂
Molecular Weight	258.36 g/mol
Synonyms	(1S)-1,2,3,4,4aβ,9,10,10aα-Octahydro-1-methylphenanthrene-1β-carboxylic acid methyl ester; Methyl (1S,4aR,10aS)-1-methyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylate; (1S)-1-Methyl-1,2,3,4,4aβ,9,10,10aα-octahydrophenanthrene-1β-carboxylic acid methyl ester; 1-Methyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid methyl ester, (1S,4aR,10aS)-; A key chiral decalin derivative.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are available upon request. We adhere to a cGMP-compliant quality management system suitable for pharmaceutical development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.