Description

3α,11β,21-Tris(Trimethylsiloxy)-5α-Pregnan-20-One o-Benzyl Oxime is a high-purity, advanced steroid intermediate featuring multiple trimethylsilyl (TMS) protecting groups. This compound is critical for enabling complex synthetic pathways in pharmaceutical research and development, offering precise control over molecular structure and reactivity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for the synthesis of novel steroid-based therapeutics and reference standards.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of complex steroid-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for the exploration and development of new therapeutic agents targeting hormonal pathways.
• Process Chemistry: Serves as a critical intermediate in scaling up synthetic routes from laboratory to pilot and commercial production.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in steroid analysis.
• Protecting Group Chemistry: The trimethylsiloxy groups are utilized for the selective protection of hydroxyl functions during complex organic syntheses.

Basic Information

Product Name	3α,11β,21-Tris(Trimethylsiloxy)-5α-Pregnan-20-One o-Benzyl Oxime
CAS No.	57325-98-1
Molecular Formula	C36H61NO4Si3
Molecular Weight	680.13 g/mol
Synonyms	5α-Pregnan-20-one, 3,11,21-tris[(trimethylsilyl)oxy]-, O-(phenylmethyl)oxime; 3,11,21-Tris-O-(trimethylsilyl)-5α-pregnan-20-one O-benzyloxime; Tris(trimethylsilyl) Pregnane Oxime Derivative; 3α,11β,21-Tris(trimethylsiloxy)-5α-pregnan-20-one O-benzyloxime; 57325-98-1; Pregnane TMS ether oxime
EINECS	Contact for details

Quality Control

Our 3α,11β,21-Tris(Trimethylsiloxy)-5α-Pregnan-20-One o-Benzyl Oxime is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.