Description

3α,17,21-Tris(Trimethylsiloxy)-20-(Methoxyimino)-5α-Pregnan-11-One is a high-purity, synthetic steroid derivative, specifically a silylated pregnane compound. This specialized intermediate is critical for pharmaceutical research and development, particularly in the synthesis of complex steroid-based active pharmaceutical ingredients (APIs). It is primarily utilized by advanced research institutions and manufacturers in the pharmaceutical and fine chemical sectors for developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex steroid hormones and related APIs.
• Research & Development: Used in medicinal chemistry for the discovery and development of new drug candidates targeting hormonal pathways.
• Process Chemistry: Serves as a protected intermediate in scalable manufacturing processes for high-value steroid products.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Biochemical Research: Utilized in studies investigating steroid receptor interactions and metabolic pathways.

Basic Information

Product Name	3α,17,21-Tris(Trimethylsiloxy)-20-(Methoxyimino)-5α-Pregnan-11-One
CAS No.	57325-75-4
Molecular Formula	C30H57NO5Si3
Molecular Weight	596.04 g/mol
Synonyms	3α,17,21-Tris(trimethylsiloxy)-20-(methoxyimino)-5α-pregnan-11-one; 5α-Pregnan-11-one, 3,17,21-tris[(trimethylsilyl)oxy]-20-(methoxyimino)-, (3α,5α,20E)-; (3α,5α,20E)-3,17,21-Tris[(trimethylsilyl)oxy]-20-(methoxyimino)pregnan-11-one; 20-(Methoxyimino)-3α,17,21-tris(trimethylsiloxy)-5α-pregnan-11-one; Steroid Silyl Ether Intermediate; TMS-protected Pregnane Derivative
EINECS	Contact for details

Quality Control

Our 3α,17,21-Tris(Trimethylsiloxy)-20-(Methoxyimino)-5α-Pregnan-11-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.