Description

11β-Hydroxy-17,21-Bis(Trimethylsiloxy)Pregn-4-Ene-3,20-Dione Bis(o-Methyl Oxime) is a key synthetic intermediate in the production of high-value steroid-based pharmaceuticals. This compound is specifically engineered for its role in complex organic synthesis, offering a protected and reactive scaffold for further chemical transformations. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within the fields of endocrinology and anti-inflammatory drug discovery.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of advanced corticosteroid analogs and other bioactive steroid molecules.
• Research & Development: Used in academic and industrial R&D laboratories for studying steroid metabolism, receptor binding, and structure-activity relationships (SAR).
• Process Chemistry: Serves as a standardized intermediate in the scale-up and optimization of API (Active Pharmaceutical Ingredient) manufacturing processes.
• Reference Standard: Can be utilized as a high-purity analytical reference standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	11β-Hydroxy-17,21-Bis(Trimethylsiloxy)Pregn-4-Ene-3,20-Dione Bis(o-Methyl Oxime)
CAS No.	57305-44-9
Molecular Formula	C31H54N2O6Si2
Molecular Weight	606.95 g/mol
Synonyms	11β-Hydroxyprednisolone 17,21-bis(trimethylsilyl) ether bis(O-methyloxime); 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 17,21-bis(trimethylsilyl) ether bis(O-methyloxime); Prednisolone derivative bis(TMS) bis(OMe) oxime; 11β-Hydroxy-17α,21-bis(trimethylsiloxy)pregna-4-ene-3,20-dione dioxime methyl ether; Steroid TMS ether oxime intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support development and cGMP-grade manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.