Description

11β-(Trimethylsiloxy)-5β-Pregnane-3,20-Dione Bis(o-Methyl Oxime) is a high-purity, advanced steroid derivative and a key synthetic intermediate in pharmaceutical research and development. This compound is valued for its precise chemical structure, which is critical for the synthesis of complex steroid-based active pharmaceutical ingredients (APIs) and reference standards. It is primarily utilized by research institutions, pharmaceutical manufacturers, and fine chemical producers engaged in the development of novel therapeutic agents, particularly in the fields of endocrinology and metabolic disease.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of complex steroid hormones and related bioactive molecules.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Research & Development: Serves as a key starting material (KSM) or advanced intermediate in medicinal chemistry programs targeting steroid receptors.
• Process Chemistry: Employed in scale-up and process optimization for the commercial manufacturing of steroid-based APIs.
• Biochemical Research: Used in studies investigating steroid metabolism, enzyme inhibition, and hormonal pathway mechanisms.

Basic Information

Product Name	11β-(Trimethylsiloxy)-5β-Pregnane-3,20-Dione Bis(o-Methyl Oxime)
CAS No.	57305-27-8
Molecular Formula	C₂₇H₄₆N₂O₃Si
Molecular Weight	474.76 g/mol
Synonyms	11β-(Trimethylsilyloxy)-5β-pregnane-3,20-dione dioxime O-methyl ether; 5β-Pregnane-3,20-dione, 11β-[(trimethylsilyl)oxy]-, dioxime, methyl ether; 11β-TMS-5β-pregnane-3,20-dione bis(O-methyloxime); 11β-Hydroxy-5β-pregnane-3,20-dione 11-trimethylsilyl ether 3,20-bis(O-methyloxime); Steroid intermediate 57305-27-8
EINECS	Contact for details

Quality Control

Our 11β-(Trimethylsiloxy)-5β-Pregnane-3,20-Dione Bis(o-Methyl Oxime) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.