Description

Hyaluronate Tetrasaccharide is a defined, low-molecular-weight oligosaccharide derived from the controlled enzymatic or chemical depolymerization of high-molecular-weight hyaluronic acid. This specific tetrameric fragment is valued for its enhanced bioavailability and targeted biological activity compared to its polymeric counterpart. It serves as a critical raw material and research standard for advanced applications in the pharmaceutical, cosmeceutical, and nutraceutical industries, where precise molecular structure and consistent quality are paramount.

Application

• Pharmaceutical R&D & Drug Delivery: Used as a model compound for studying hyaluronan-receptor interactions (e.g., CD44, RHAMM) and as a building block for designing targeted drug delivery systems.
• Advanced Cosmetic Actives: Incorporated into anti-aging, wound-healing, and moisturizing formulations for its potential to stimulate collagen synthesis and cellular regeneration at the epidermal level.
• Biochemical Research: Serves as a standard and substrate in enzymatic assays (e.g., for hyaluronidases) and for investigating the role of hyaluronan fragments in inflammation, angiogenesis, and signaling pathways.
• Nutraceutical Development: Explored as a bioactive ingredient in supplements aimed at supporting joint health, skin hydration, and gastrointestinal integrity due to its potential anti-inflammatory properties.
• Medical Device Coatings: Investigated for use in coating implants or scaffolds to improve biocompatibility, reduce fibrosis, and promote tissue integration.

Basic Information

Item	Detail
Product Name	Hyaluronate Tetrasaccharide
CAS No.	57282-61-8
Molecular Formula	C56H84N4O43
Molecular Weight	1549.26 g/mol
Synonyms	Hyaluronic Acid Tetrasaccharide; Tetrasaccharide of Hyaluronic Acid; Hyaluronan Tetramer; HA4; (2S,3R,4S,5S,6R)-2-[[(2S,3S,4R,5R,6R)-6-[[(2S,3R,4R,5R,6R)-3-Acetamido-2-[(2S,3R,4R,5R,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy]-5-[(2-carboxyacetyl)amino]-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol; Sodium Hyaluronate Tetrasaccharide
EINECS	Contact for details

Quality Control

Our Hyaluronate Tetrasaccharide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for research and cGMP-grade manufacturing. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 10 ppm
Bacterial Endotoxins	< 0.5 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.