Description

Mannose-6-Phosphate Rich Phosphomannan is a high-purity, biologically active polysaccharide derivative characterized by its enriched mannose-6-phosphate (M6P) residues. This compound is critical for research and development in targeted drug delivery and cellular signaling pathways, leveraging the specific recognition of M6P by cell surface receptors. It is primarily utilized by pharmaceutical researchers, biochemists, and manufacturers in the life sciences sector for applications in lysosomal enzyme targeting, glycobiology studies, and the development of advanced therapeutic conjugates.

Application

• Lysosomal Enzyme Targeting & Delivery: Serves as a key ligand for the cation-independent mannose-6-phosphate receptor (CI-MPR), facilitating the targeted delivery of therapeutic enzymes to lysosomes.
• Glycobiology & Biochemistry Research: Used as a standard or inhibitor in studies of carbohydrate-protein interactions, receptor binding assays, and metabolic pathway analysis.
• Drug Conjugate Development: Incorporated into bioconjugates and nanoparticles to enhance tissue-specific targeting, particularly for treatments of lysosomal storage disorders.
• Cell Signaling Studies: Employed to investigate M6P-mediated cellular uptake mechanisms, intracellular trafficking, and signal transduction processes.
• Diagnostic Reagent Formulation: A component in the development of diagnostic kits and assays for measuring enzyme activity or receptor presence.
• Pharmaceutical Intermediate: Acts as a critical starting material or intermediate in the synthesis of more complex glycotherapeutic agents.

Basic Information

Item	Detail
Product Name	Mannose-6-Phosphate Rich Phosphomannan
CAS No.	57034-83-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Phosphomannan P; M6P-Phosphomannan; Mannose-6-Phosphomannan; Phosphorylated Mannan; Yeast Phosphomannan (M6P-rich); Poly(Mannose Phosphate); Glycan M6P Ligand; CI-MPR Ligand
EINECS	Contact for details

Quality Control

Our Mannose-6-Phosphate Rich Phosphomannan is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including assessment of M6P content, polysaccharide purity, and molecular weight distribution to ensure consistent biological activity and lot-to-lot reproducibility. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term stability, consider storage under inert atmosphere or desiccation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (M6P Content)	≥ 85% (by HPLC or colorimetric assay)
Purity (Polysaccharide)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, phosphate buffers
Biological Activity	Positive in receptor binding assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.