Description

4-(2,5-Dioxo-2,5-Dihydro-Pyrrol-1-Yl)-Phthalic Acid is a high-purity, functionalized phthalic acid derivative featuring a maleimide moiety, making it a versatile and valuable bifunctional linker for advanced material synthesis. This compound is critical for creating covalent bonds with thiol groups under mild conditions, enabling the precise construction of polymers, bioconjugates, and surface coatings. It is primarily sought by R&D chemists and process engineers in the pharmaceutical intermediates, polymer science, and specialty chemical sectors for developing targeted drug delivery systems, cross-linked hydrogels, and functionalized nanomaterials.

Application

• Pharmaceutical Intermediate: Serves as a key building block for synthesizing antibody-drug conjugates (ADCs) and other bioconjugates by linking payloads to targeting molecules.
• Polymer Cross-linking Agent: Used to introduce covalent cross-links in hydrogel formulations for medical devices, controlled release systems, and tissue engineering scaffolds.
• Surface Functionalization: Enables the modification of nanoparticles, quantum dots, and solid supports (e.g., gold surfaces, silica beads) with specific functional groups for biosensing and diagnostics.
• Specialty Resin Synthesis: A monomer for producing high-performance, heat-resistant polyimides and other advanced polymers with tailored properties.
• Protein and Peptide Modification: Facilitates site-specific labeling or immobilization of proteins and peptides via cysteine residues for research and assay development.
• Material Science Research: Employed in academic and industrial R&D to develop novel smart materials, self-healing polymers, and responsive coatings.

Basic Information

Product Name	4-(2,5-Dioxo-2,5-Dihydro-Pyrrol-1-Yl)-Phthalic Acid
CAS No.	56896-91-4
Molecular Formula	C14H9NO6
Molecular Weight	287.23 g/mol
Synonyms	1-(3,4-Dicarboxyphenyl)-1H-pyrrole-2,5-dione; 4-Maleimidophthalic Acid; 1H-Pyrrole-2,5-dione, 1-(3,4-dicarboxyphenyl)-; N-(3,4-Dicarboxyphenyl)maleimide; 4-(Maleimido)phthalic Acid; Phthalic Acid, 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-; 4-(2,5-Dioxopyrrolidin-1-yl)phthalic Acid (tautomeric form)
EINECS	Contact for details

Quality Control

Every batch of 4-(2,5-Dioxo-2,5-Dihydro-Pyrrol-1-Yl)-Phthalic Acid is manufactured under a strict quality management system. We employ advanced analytical techniques including HPLC, NMR, and FT-IR to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. This material should be stored separately from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.