Description

2-Propyn-1-Ol, 3-(Tetrahydro-2H-Pyran-2-Yl)- (9Ci) is a specialized organic compound featuring a propargyl alcohol moiety protected by a tetrahydropyranyl (THP) group. This chemical matters as a versatile protected synthetic intermediate, enabling controlled reactivity in complex organic synthesis. It is primarily needed by research and development chemists and process engineers in the pharmaceutical and fine chemical industries for constructing advanced molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly where the propargyl functionality must be temporarily masked.
• Organic Synthesis Reagent: Used in multi-step synthesis for the controlled introduction of acetylene units in complex molecules like natural products and agrochemicals.
• Polymer Chemistry: Acts as a monomer or chain-transfer agent in the development of specialty polymers with tailored properties.
• Click Chemistry: The protected alkyne group can be deprotected for subsequent use in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, a cornerstone of bioconjugation and materials science.
• Ligand and Catalyst Development: Employed in the preparation of novel ligands and organometallic catalysts for asymmetric synthesis.
• Academic and Industrial R&D: A valuable tool for methodological development and exploratory chemistry in both university and corporate research laboratories.

Basic Information

Product Name	2-Propyn-1-Ol, 3-(Tetrahydro-2H-Pyran-2-Yl)- (9Ci)
CAS No.	56850-02-3
Molecular Formula	C8H12O2
Molecular Weight	140.18 g/mol
Synonyms	3-(Tetrahydro-2H-pyran-2-yloxy)-1-propyne; 2-Propyn-1-ol, 3-(tetrahydro-2H-pyran-2-yl)-; THP-Protected Propargyl Alcohol; Propargyl Alcohol THP Ether; 2-(Prop-2-yn-1-yloxy)tetrahydro-2H-pyran; 3-(Oxan-2-yloxy)prop-1-yne; 2-Propynyl Tetrahydropyranyl Ether
EINECS	Contact for details

Quality Control

Our 2-Propyn-1-Ol, 3-(Tetrahydro-2H-Pyran-2-Yl)- is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance as a synthetic intermediate. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.