Description

Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid is a highly rigid, cage-like dicarboxylic acid derivative of the bicyclo[1.1.1]pentane (BCP) scaffold. This compound matters as a valuable, non-traditional bioisostere for para-substituted benzene rings and linear alkynes, offering improved metabolic stability, solubility, and reduced conformational flexibility in drug design. Pharmaceutical and agrochemical researchers need it for the development of novel active ingredients, leveraging its unique three-dimensional structure to optimize the physicochemical properties of lead compounds.

Application

• Pharmaceutical Intermediate: A key building block in medicinal chemistry for creating novel drug candidates, particularly as a bioisostere in protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, where its rigid structure can enhance target binding and environmental stability.
• Material Science Research: Serves as a precursor for synthesizing rigid, high-performance polymers and advanced organic frameworks with unique mechanical and thermal properties.
• Chemical Biology Probes: Employed in the design of molecular probes and tools to study biological systems and enzyme functions.
• Ligand Development: Utilized in organometallic chemistry and catalysis to create novel, sterically demanding ligands for transition metal complexes.

Basic Information

Product Name	Bicyclo[1.1.1]pentane-1,3-dicarboxylic Acid
CAS No.	56842-95-6
Molecular Formula	C8H10O4
Molecular Weight	170.16 g/mol
Synonyms	1,3-Bicyclo[1.1.1]pentanedicarboxylic acid; BCP-1,3-dicarboxylic acid; [1.1.1]Propellane-1,3-dicarboxylic acid; 3-Carboxybicyclo[1.1.1]pentane-1-carboxylic acid; BCP diacid
EINECS	Contact for details

Quality Control

Our Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of atmospheric moisture, which may affect product quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.