Description

(R)-(+)-1-(1-Phenylethyl)-1H-Imidazole-5-Carboxylic Acid is a high-purity, single-enantiomer chiral building block and intermediate of significant importance in advanced organic synthesis. Its value lies in its structural motif, which is integral to the development of active pharmaceutical ingredients (APIs) and other fine chemicals requiring precise stereochemistry. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries who are developing novel compounds with specific biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Asymmetric Catalyst Ligand Precursor: Serves as a starting material for synthesizing sophisticated ligands used in enantioselective catalysis, crucial for producing optically pure compounds.
• Agrochemical Synthesis: Used in the development of novel, enantiomerically pure pesticides and herbicides where specific chirality enhances efficacy and reduces environmental impact.
• Academic & Industrial Research: A valuable tool for methodological studies in organic chemistry, including new reaction development and stereochemistry investigations.
• Fine Chemical Production: Employed in the multi-step synthesis of complex molecules for electronics, advanced materials, and other high-value specialty applications.

Basic Information

Product Name	(R)-(+)-1-(1-Phenylethyl)-1H-Imidazole-5-Carboxylic Acid
CAS No.	56649-48-0
Molecular Formula	C₁₂H₁₂N₂O₂
Molecular Weight	216.24 g/mol
Synonyms	(R)-1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid; (R)-(+)-1-(α-Methylbenzyl)imidazole-5-carboxylic Acid; (R)-PEICA; (R)-1-Phenylethylimidazole-5-carboxylic Acid; (R)-1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid; (R)-1-(1-Phenylethyl)imidazole-5-carboxylic acid; (R)-1-(α-Phenylethyl)imidazole-5-carboxylic Acid
EINECS	Contact for details

Quality Control

Our (R)-(+)-1-(1-Phenylethyl)-1H-Imidazole-5-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, NMR for structural confirmation, and standard purity assays. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor quality documentation to meet specific regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.