Description

Benzo(A)Pyrene-9,10-Dihydrodiol is a crucial dihydrodiol metabolite of the polycyclic aromatic hydrocarbon benzo[a]pyrene, a well-studied environmental pollutant. This compound serves as a vital intermediate in the metabolic activation pathway of benzo[a]pyrene, making it an essential reference standard and research chemical for toxicological and metabolic studies. It is primarily used by researchers and analytical laboratories in the fields of environmental science, pharmacology, and cancer research to investigate mechanisms of carcinogenesis, DNA adduct formation, and detoxification pathways.

Application

• Toxicological Research Standard: Used as a certified reference material (CRM) for studying the metabolic activation and carcinogenic mechanisms of benzo[a]pyrene.
• Environmental Analysis: Serves as a key analytical standard in HPLC, GC-MS, or LC-MS methods for detecting and quantifying polycyclic aromatic hydrocarbon (PAH) metabolites in environmental and biological samples.
• Biochemical Research: Employed in in vitro and in vivo studies to understand cytochrome P450-mediated metabolism and the formation of reactive diol epoxides.
• DNA Adduct Studies: Critical for research into the formation and repair of DNA adducts, which is fundamental to understanding chemical carcinogenesis.
• Pharmacology & Drug Metabolism: Used to investigate enzyme kinetics, inhibition, and the efficacy of chemopreventive agents against PAH-induced toxicity.
• Quality Control & Method Development: Acts as a purity standard for calibrating analytical instruments and validating new testing protocols in analytical and contract research laboratories.

Basic Information

Product Name	Benzo(A)Pyrene-9,10-Dihydrodiol
CAS No.	56484-47-0
Molecular Formula	C₂₀H₁₄O₂
Molecular Weight	286.32 g/mol
Synonyms	Benzo[a]pyrene-9,10-dihydrodiol; 9,10-Dihydroxy-9,10-dihydrobenzo[a]pyrene; trans-Benzo[a]pyrene-9,10-dihydrodiol; BP-9,10-diol; B[a]P-9,10-dihydrodiol; 9,10-Dihydrobenzo[a]pyrene-9,10-diol; Benzo(a)pyrene 9,10-diol
EINECS	Contact for details

Quality Control

Every batch of Benzo(A)Pyrene-9,10-Dihydrodiol is produced and analyzed under strict quality management protocols. Our products undergo rigorous purity and identity verification using advanced analytical techniques including HPLC, GC-MS, and NMR spectroscopy to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and chromatographic data is provided with each shipment to guarantee traceability and support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. For long-term storage, keep the container sealed in a dry, freezer-safe environment. Allow the product to equilibrate to room temperature in the sealed container before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, methanol, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.