Description

5-(Trifluoromethyl)Furan-3-Carboxylic Acid is a high-value fluorinated heterocyclic building block essential for advanced organic synthesis. This compound matters for its unique trifluoromethyl-substituted furan scaffold, which imparts desirable properties like enhanced metabolic stability and lipophilicity to target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group can improve biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for functionalized polymers and advanced organic materials with tailored electronic or surface properties.
• Ligand and Catalyst Development: Employed in the synthesis of novel chelating ligands or organocatalysts for asymmetric synthesis and transition metal catalysis.
• Fluorine Chemistry Studies: A valuable substrate for investigating new fluorination reactions and the behavior of fluorinated heterocycles.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	5-(Trifluoromethyl)Furan-3-Carboxylic Acid
CAS No.	56286-81-8
Molecular Formula	C6H3F3O3
Molecular Weight	180.08 g/mol
Synonyms	3-Furoic acid, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)-3-furancarboxylic acid; 5-(Trifluoromethyl)furan-3-carboxylic acid; 3-Carboxy-5-(trifluoromethyl)furan; α,α,α-Trifluoro-5-furan-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)Furan-3-Carboxylic Acid is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and fluorides. The container must be kept tightly closed in a dry and inert atmosphere due to the compound's sensitivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.