Description

[1-[(2,2-Dimethylpropylidene)Amino]-1-Methylethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organophosphorus compound featuring a protected phosphonic acid group, making it a valuable intermediate in advanced organic synthesis. Its primary commercial value lies in its role as a key building block for the preparation of novel α-aminophosphonic acid derivatives, which are of significant interest in medicinal and agrochemical research. This high-purity reagent is essential for R&D chemists and process development scientists working in pharmaceutical development, crop protection, and materials science, where precise molecular construction is critical.

Application

• Pharmaceutical Intermediate: Serves as a protected precursor in the synthesis of α-aminophosphonic acids and their analogs, which are investigated for their bioactive properties, including enzyme inhibition.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, plant growth regulators, and other crop protection agents that utilize phosphonate chemistry.
• Ligand and Catalyst Development: Acts as a starting material for creating specialized phosphonate-containing ligands used in asymmetric catalysis and metal complexation.
• Peptidomimetics Research: Employed to incorporate phosphonate moieties into peptide backbones, creating hydrolytically stable analogs for drug discovery.
• Material Science Precursor: Utilized in the synthesis of functionalized monomers or surface-modifying agents for advanced polymers and hybrid materials.
• Chemical Biology Probes: Facilitates the development of activity-based probes and diagnostic agents targeting phosphate-metabolizing enzymes.

Basic Information

Product Name	[1-[(2,2-Dimethylpropylidene)Amino]-1-Methylethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	56196-70-4
Molecular Formula	C14H34NO3PSi2
Molecular Weight	351.57 g/mol
Synonyms	1-[(2,2-Dimethylpropylidene)amino]-1-methylethylphosphonic Acid Bis(trimethylsilyl) Ester; (1-[(2,2-Dimethylpropylidene)amino]-1-methylethyl)phosphonic Acid Bis(trimethylsilyl) Ester; Phosphonic Acid, P-[1-[(2,2-dimethylpropylidene)amino]-1-methylethyl]-, Bis(trimethylsilyl) Ester; Neopentylideneamino Isopropylphosphonate Bis(TMS) Ester; (1-(Neopentylideneamino)-1-methylethyl)phosphonic Acid Bis(trimethylsilyl) Ester; TMS-Protected α-Aminophosphonate Ester
EINECS	Contact for details

Quality Control

Every batch of [1-[(2,2-Dimethylpropylidene)Amino]-1-Methylethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is manufactured and analyzed under strict quality management protocols to ensure consistency and reliability for sensitive synthetic applications. Our products undergo rigorous quality testing, including chromatographic purity analysis and structural confirmation, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.