Description

[3-(Isothiocyanatoamino)Propyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organosilicon-protected phosphonic acid derivative that serves as a critical synthetic intermediate. Its value lies in its dual functionality, offering a protected phosphonate group and a reactive isothiocyanate moiety, enabling controlled, sequential chemical modifications. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors who require advanced building blocks for drug discovery, ligand synthesis, and the development of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly those targeting bone diseases or requiring phosphonate-based bioisosteres.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and plant growth regulators with enhanced activity.
• Ligand and Chelator Design: Serves as a precursor for creating sophisticated ligands for metal catalysis, medical imaging agents, or metal-chelating polymers.
• Surface Modification Agent: The protected phosphonic acid group can be used to functionalize metal oxide surfaces (e.g., titanium, silicon) for advanced materials science applications.
• Peptide and Protein Conjugation: The isothiocyanate group allows for selective coupling to amine groups, useful in bioconjugation and probe development.
• Chemical Research & Development: A versatile reagent in organic synthesis for introducing phosphonate functionality under mild, silyl-protected conditions.

Basic Information

Product Name	[3-(Isothiocyanatoamino)Propyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	56051-86-6
Molecular Formula	C10H25N2O3PSi2
Molecular Weight	308.47 g/mol
Synonyms	Bis(trimethylsilyl) [3-(isothiocyanatoamino)propyl]phosphonate; 3-Isothiocyanatopropylphosphonic Acid Bis(trimethylsilyl) Ester; Phosphonic Acid, P-[3-[(Isothiocyanato)amino]propyl]-, Bis(trimethylsilyl) Ester; (3-Isothiocyanatopropylphosphonic Acid Bis-trimethylsilyl Ester); ATMPP-BTMS; NSC 339063
EINECS	Contact for details

Quality Control

Every batch of [3-(Isothiocyanatoamino)Propyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is produced and tested under strict quality management systems to ensure consistency and reliability for your synthetic workflows. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by NMR/HPLC), identity confirmation, and moisture content. Our commitment to supply chain integrity and documentation transparency supports your compliance needs in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C (refrigerated) to maximize stability, due to its moisture-sensitive and light-sensitive nature. Allow the container to reach room temperature before opening to minimize condensation and moisture ingress. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.