Description

[1-(Isothiocyanatoamino)Ethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organosilicon-protected phosphonate derivative, serving as a critical synthetic intermediate. Its value lies in its dual functionality, offering a protected phosphonic acid group and a reactive isothiocyanate moiety for selective conjugation or further chemical elaboration. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and advanced material science, where precise molecular construction is required.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting bone diseases or requiring phosphonate-based bioisosteres.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, plant growth regulators, or fungicides with phosphonate activity.
• Ligand and Chelator Precursor: Serves as a starting material for creating sophisticated ligands used in catalysis, metal extraction, or diagnostic imaging agents.
• Surface Modification Agent: Employed to functionalize materials (e.g., silica, metals) with specific reactive groups for adhesion promotion or biocompatibility enhancement.
• Peptide and Protein Conjugation: The isothiocyanate group allows for covalent attachment to amino groups, useful in bioconjugation and probe development.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for synthesizing specialty polymers with unique thermal or chemical resistance properties.
• Chemical Biology Research: A valuable tool for probing enzyme activity or developing activity-based probes targeting hydrolases or other enzymes.

Basic Information

Product Name	[1-(Isothiocyanatoamino)Ethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	56051-82-2
Molecular Formula	C9H23N2O3PSi2
Molecular Weight	294.44 g/mol
Synonyms	Bis(trimethylsilyl) [1-(isothiocyanatoamino)ethyl]phosphonate; Phosphonic acid, [1-[(isothiocyanato)amino]ethyl]-, bis(trimethylsilyl) ester; [1-(Isothiocyanatoamino)ethyl]phosphonic Acid Bis(trimethylsilyl) Ester; TMS-Protected Isothiocyanatoaminophosphonate; (1-Isothiocyanatoaminoethyl)phosphonic Acid Bis(TMS) Ester
EINECS	Contact for details

Quality Control

Our production of [1-(Isothiocyanatoamino)Ethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and purity for demanding R&D and scale-up applications. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.