Description

(3E,5R,6R,7E)-1-[(2R)-6-Hydroxy-2,8-Dimethyl-2H-1-Benzopyran-2-Yl]-4,8,12-Trimethyl-3,7,11-Tridecatriene-5,6-Diol is a high-purity, stereochemically defined chromanol derivative with significant biological activity. This compound is valued for its role as a key synthetic intermediate and reference standard in advanced pharmaceutical and nutraceutical research. It is primarily sought by R&D and quality control laboratories in the pharmaceutical, cosmetic, and fine chemical industries for developing novel therapeutic agents and high-value bioactive compounds.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel vitamin E analogs and other chromanol-based therapeutic agents.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related active pharmaceutical ingredients (APIs) and natural products.
• Nutraceutical Research: Serves as a precursor in the development of advanced antioxidant and anti-inflammatory dietary supplements.
• Cosmetic Actives: Investigated for use in premium skincare formulations targeting oxidative stress and skin aging.
• Biochemical Research: Employed in studies of lipid peroxidation, antioxidant mechanisms, and cell signaling pathways.
• Fine Chemical Synthesis: A versatile chiral synthon for constructing complex natural product frameworks and specialty chemicals.

Basic Information

Product Name	(3E,5R,6R,7E)-1-[(2R)-6-Hydroxy-2,8-Dimethyl-2H-1-Benzopyran-2-Yl]-4,8,12-Trimethyl-3,7,11-Tridecatriene-5,6-Diol
CAS No.	55831-27-1
Molecular Formula	C₂₉H₄₂O₄
Molecular Weight	454.64 g/mol
Synonyms	2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltrideca-3,7,11-trienyl)chroman-6-ol (all-rac-α-Tocopherol related isomer); (2R)-2,5,7,8-Tetramethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydro-2H-chromene-6-ol (specific stereoisomer); Chromanol derivative; Vitamin E analog intermediate; Tocopherol intermediate; Tocol derivative
EINECS	Contact for details

Quality Control

Our (3E,5R,6R,7E)-1-[(2R)-6-Hydroxy-2,8-Dimethyl-2H-1-Benzopyran-2-Yl]-4,8,12-Trimethyl-3,7,11-Tridecatriene-5,6-Diol is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including chiral HPLC, NMR, and mass spectrometry to confirm identity, stereochemical purity, and chemical purity. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry environment. Due to its hygroscopic and easily oxidized nature, prolonged exposure to air, moisture, or elevated temperatures should be avoided. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC, Area %)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% (specified stereoisomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.